General Purpose 2D and 3D CAD Programs

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Alibre - Design suite that provide comprehensive modeling, detailing, interoperability, downstream applications
AutoCAD (sites, reviews) - the most popular CAD program in the world, a standard for design software, by Autodesk
Autodsys - offers IntelliCAD-based software AcceliCAD, AcceliARCH (IntelliCAD sites, ArchT reviews)
Bricscad - IntelliCAD based, 2D/3D CAD, by Bricsys
CADDIT - offers 2D and 3D CAD, Australia and New Zealand
Cadidesk - AutoCAD-compatible drawing program by IntelliFrance
CADopia - sells version of IntelliCAD (sites, reviews)
CADpercept - CAD design, drafting, detailing, conversion software for mechanical, architectural, structural purposes, from MMTechnologies
CADVANCE - from FIT Inc. (sites, reviews)
CMS IntelliCAD - CAD Software for engineers, architects, consultants, AutoCAD compatible, drawing tools, by CMS
CtrlCAD - 2D source code C++ graphic library to build CAD/GIS applications, supports DWG/ DXF format
DataCAD (sites, reviews)
DesignCAD 3D MAX - offers 3D modeling, 2D drafting and many other features of more expensive, high-end CAD programs, from Upperspace. (reviews)
FastCAD - by Evolution Computing (reviews)
FelixCAD (see PowerCAD Professional)
freeCAD - a basic 3D CAD with advanced motion simulation capabilities, suitable for anyone interested in learning to use CAD for free before upgrading to a commercial application
Generic CADD - website of GenericCadd.com, a CAD dealership that continues to offer support and information for users of this now-discontinued Autodesk program
Graphite - 2D drafting and 3D from Ashlar Vellum, available for PC and Mac (replaces Vellum Draft)
GStarCAD - IntelliCAD based CAD software, by Gstarsoft
IDRAW 2000 - by Design Futures
IGEStoolbox - a standalone, lightweight CAD program for viewing or plotting IGES files without converting files to other formats, cutting sections in surfaces and transforming and creating geometry, from Cornerstone Technology.
IntelliCAD - AutoCAD-compatible, uses DWG as native file format, licenses to developers, by the IntelliCAD Technology Consortium (sites, reviews)
KEYCREATOR new - general purpose, full featured CAD, used for mechanical application, formerly known as CADKEY (sites, reviews)
MicroStation - industrial strength, very popular (2nd only to AutoCAD), Bentley Systems, Inc. (sites, reviews)
OrthoGraph - makers of data acquisition software for graphical real estate measurement
PowerCAD Pro v6 - offers AutoCAD compatibility and customization, supports paper and model space and xrefs, and includes utilities to convert AutoLISP and ADS program code, menus, dialog boxes and toolbars (formerly FelixCAD), from GiveMePower Inc. (reviews)
ProgeCAD - CAD system compatible with the AutoCAD product line, by ProgeSOFT
PunchCAD - extensive collection of 2D/3D modeling tools, training videos
QuickCAD - entry-level CAD, by Autodesk
StreamCAD - easy translation to other languages, editable user interface, text and dialogs stored in XML files, data stored in XML and DWG/DXF files
TurboCAD - full function CAD program, favored by construction, hobbyists (sites, reviews)
Vdraft - from SoftSource, DWG-based CAD system (reviews)
VectorWorks new - full featured 3D CAD program, runs on Windows, Mac, by Nemetschek (sites, reviews)
VersaCAD - production-level CAD for engineers, draftspersons, and others the architectural, civil engineering, construction, and mechanical industries, by Archway Systems